APC is a tumor suppressor and acts in the Wnt signaling pathway to prevent the TCF complex from turning on Wnt-responsive genes. Mice that lack the gene encoding TCF4 do not have the ability to maintain the pool of proliferating gut stem cells needed to renew the gut lining. What do you predict will happen in mice that lack the APC gene

Answers

Answer 1

Answer:

As APC is indicated as a tumor suppressor, lack of APC would lead to tumor development in the mutated mice.

Explanation:

The wnt signaling pathway plays an important role in controlling stem cell proliferation. Stem cells are present in the gut and other locations where they are required to be replenished after short intervals. In the gut, the gut epithelial is exposed to a very tough environment i.e. digestive acids. Thus it is replenished where the new stem cells originate from underlying stem cells.

Axin binding is the major component of this process. However, the unaffected axin leads to binding with a component termed TCF. TCF4 genes include cell cycle factors (such as myc) that encourage cell regeneration.

When the ligand is absent and APC is present, the axin bound with APC to form a team that directs and controls the cell regeneration.

Thus, if APC is not expressed in a cell, beta-catenin in the axin is available to bind to TCF inducing wnt response element genes that stimulate cell proliferation.

The result in tissue level is an enhanced rate of cell growth which leads to tumor.  


Related Questions

Use the drop-down menus to identify the organelles labeled on the animal cell to the right. Label A Label B Label C Label D

Answers

The identification of the organelles labeled on the animal cell to the right are:

Label A :  D  Label B :  BLabel C :  CLabel D :  A  

What is an animal cell?

An animal cell is a multicellular cell that is present in all animals. The main distinction between an animal cell is that it is made up of without cell wall.

Animal cells do not contain the things such as vacuole chloroplast that are present in plant cells and the cell walls. They are not unicellular because animals are always multicellular.

As the animal cell is a multicellular cell it contains cell organelles like mitochondria endoplasmic reticulum, ribosome, a nucleus that contain the genetic material of the animal.

Thus, the correct options are Label A :  D, Label B : B, Label C :  C, and Label D :  A.

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what is an organism that obtains energy from the sun through the process of photosynthesis?

Answers

Answer:

autotrophs

Explanation:

PLZ HELP ASAP (BRAINLIEST INCLUDED)

Which of the following are seen when the solar winds collide with Earth's atmosphere?

Auroras
Lunar eclipses
Solar eclipses
Tides

Answers

Answer:

Auroras

Explanation:

Hope this helped :)

Answer:

Auroras

Explanation:

Auroras often form near Earth's north and south magnetic poles, but sometimes they can also occur near the equator. Their position all depends on solar winds. The stronger the solar wind is, the bigger and brighter the aurora is.

hope this helps ♥

could you please help me ​

Answers

Answer: 7. Salt 8. Luteal or decline. 9. Lungs. Brainliest?

Explanation:

The thyroid gland produces a substance
containing iodine that helps regulate growth.
Goiter is an enlargement of the thyroid gland
caused by a lack of iodine in the diet. Goiter
is uncommon in coastal areas where people
eat seafood that contains a form of iodine.
It is more common inland, where people
eat food that has been grown in soil
lacking iodine.
Which phrase restates the cause of the
disease goiter, as given in the passage?
(1) eating too much fish
(2) eating too little of foods high in iodine
(3) exposure to a bacterium found in iodine
(4) fertilizing the soil with iodine
(5) inheriting a defective thyroid gene

Answers

Answer:

eating too little of foods high in iodine

Explanation:

Iodine deficiency lead to goiter that is why it is necessary to consume food rich in iodine like taking iodized salt or sea foods which prevent this. This lead to goiter because, your thyroid gland need iodine to repair tissues, produce thyroid hormones, aid metabolism and for proper growth,therefore deficiency of it will result in non of the following functions.

please help no links or ill report you

Answers

Answer:

the movement of carbon dissolved in ocean water into rocks

All of these events are characteristic of an El Niño event except:
A- the Midwestern United States experiences more rainfall than usual.
B- the usual South America-to-Southeast Asia winds ease.
C- South Africa, Japan, and Canada experience warmer than usual weather.
D- ocean surface temperatures are lower than usual.
E- storms form off the coast of California.

Answers

Answer:

B- the usual South America-to-Southeast Asia winds ease.

Explanation:

The usual South America-to-Southeast Asia winds did not blow from west to east because of El Nino event. In normal condition, the winds blow easterly from South America-to-Southeast Asia which means from west to the east direction but due to El Nino event, the wind blows is reversed which causes the blowing of winds towards westerlies which means from east to the west direction so the usual blowing of winds from South America-to-Southeast Asia  did not occur.

characteristics of plasmodium​

Answers

Explanation:

Characteristics of Plasmodium

They characteristically show the presence of apical complex.

Apical complex consists of polar rings, rhoptries, micronemes, mitcochondrions, microtubules and microspores

Organs for locomotion

They show slight amoeboid change of form

The parasite in their life cycle shows an alternation of generation accompanied by an alternation of host

Which of the following is a disadvantage of hydrogen fuel?

Answers

Answer:

The answer is A. It is expensive to produce and transport

Explanation:

Drafts, wind, or physical placement of buildings can make it difficult for investigators to determine where a fire started.

A. True

B. False

Answers

Answer:

A. True

Explanation:

I took it on a test and it was correct ; )

Answer:

true

took the test

True or false: (I really need help, if you saw this and responded thank you. :)

Answers

Answer:

False

Explanation:

heterozygous means there are two different alleles. So the trait would be written as Bb. I can't write the other option because it counts it as a swear word but it means that there are two identical alleles. So it would be written as BB

Answer:

False

Explanation:

A student must complete the column on the table that list the dates of the full
moons. What are the most likely dates of the full moons? *
Dates of New Moons Dates of Full Moons
February 10
March 11
April 10
May 9
February 5, March 7, April 5, May 4
0
February 15, March 17, April 15, May 14
February 25, March 27April 25, May 24
February 29, March 31, April 29, May 28
Other:

Answers

Answer:

February 25, March 27, April 25, May 24

Explanation:

I did the science moon phases for this! I would explain if it showed the graph and everything.

Good luck with it!

The Moon's orbit, which completes one full spin in 27 days, 7 hours, and 43 minutes, is the source of this motion. It compels the Moon to move 12–13 degrees east every day. February 25, March 27, April 25, May 24 Thus option C is correct.

What is Full Moons?

When the Moon fills the sky in a perfect circle, it is said to be full.

We can only view the portions of the Moon that are illuminated by other objects because the Moon doesn't create any visible light on its own.

This change causes Moonrise to occur every day around 50 minutes later and necessitates a slightly longer Earth rotation to bring the Moon into view.

Technically, the Moon's “fullness” lasts only a brief period of time.

Therefore, the Moon can appear to be full to the unaided eye for as long as three days.

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PLEASE HELP I HAVE AN EXAM !!!
With the aid of a diagram, show how secretion of cortisol is regulated at the primary, secondary, and tertiary levels

P.S. If you do not know the answer, could you please provide the link for the site where there is an answer. Appreciate your help !!!

Answers

Explanation:

Cortisol secretion is regulated by the hypothalamic hormone, CRH, and the pituitary hormone, ACTH, in the hypothalamus-pituitary-adrenal axis. Cortisol is known as a stress hormone involved in the response to physical and/or emotional stress.

.
What is a blastula?

a hollow ball of cells
a hollow tube of cells
a solid ball of cells
a long sheet of cell

Answers

a hollow ball of cells

in your own words, why do you think the mining transitioned from underground tunnels to an open pit​

Answers

Answer:

Open-pit mines are utilized when stores of industrially helpful metal or shakes are found close to the surface. ... Interestingly, minerals that have been discovered underground however are hard to recover because hard rock can be arrived at utilizing a type of underground mining.

Explanation:

gib brain

PLEASE HELP, I NEED THIS TO PASS xx,

A hypotonic solution has a lower concentration of solutes than a blood cell. Explain what
happens when a blood cell is placed in a hypotonic solution.

A: the blood cell soaks up salt.

B: the blood cell swells with water.

C: the blood cell stays the same.

D: the blood cell loses water.

Answers

Answer:

B

Explanation:

Mark as branlist

In a separate location, take notes from the sources you've identified. The notes will provide details for your presentation
While taking notes, you may want to use these reading strategies C. Write down one or two pieces of information per
topic that you intend to use in your presentation.
Topic
Chemical reactions of fossil fuels
Difference between biomass and fossil fuels
Comparing biomass with other renewable
energy sources
Making energy choices locally

Answers

Answer:

CH4 + 2O2 -----> CO2 + 2H2O.

Explanation:

CH4 + 2O2 -----> CO2 + 2H2O is the chemical reaction of burning of fossil fuels. The main difference between biomass and fossil fuels is that biomass is biological material which can be derived from living whereas Fossil fuel such as coal, oil and gas are derived from biological material. Biomass is renewable because a new crop can be grown after each harvest, and biomass is a low carbon fuel. Biomass is renewable just like other renewable energy sources because both can be used again and again. The energy choices locally occurs according to the availability of energy resources in that locality.

HELP ME

Explain how a person's mother and father can both exhibit or show a trait but their children may
not exhibit the trait.

Answers

Answer:

a child inherits 50% of the each parents genes.

Explanation:

the percentage goes all the way back to grand parents and great grand parents because your parents also inherited 50 percent of each of their parents. and their parents i herit from ther parents and so on. therefore when u inherit your genes and triats you also inherit some of your grandparents genes. that why some traits might be in the person's mother or father but not in the child because genes are divided into two with each generation.

HELP MEE

The diagram to the right shows the X chromosomes in a female fruit fly and the X and Y
chromosomes in a male fruit fly. The two fruit flies are crossed with each other. Fill in the two
chromosomes below illustrating the female offspring of the fruit flies.

Answers

Answer:

the question is not correct

Explanation:

send correct question

Answer:

A

Explanation:

Fresh steak is said to have both negative and positive redox potential. Discuss how the redox potential affects the microbial ecology of the food​

Answers

Answer:

Increases redox potential decreases microbial growth inside food.

Explanation:

The redox potential is considered as one of the most complex indicators of the physical conditions of microbial cultures. The measurement of redox potential could be very useful for the determination of qualitative and quantitative parts of the microbial contamination. During the bacterial growth, the redox potential of the medium decreases. Redox potential is a measure of the tendency of a biological species which can be acquire or lose electrons through ionization. If the redox potential of the medium is increases, there will be lower growth of microbes in the food and vice versa.

If the birth rate and death rate are balanced in a population, how might a population increase in size?
I

Answers

Answer:

Population change is governed by the balance between birth rates and death rates. If the birth rate stays the same and the death rate decreases, then population numbers will grow. If the birth rate increases and the death rate stays the same, then population will also grow

Explanation:

Natural increase in a population occurs where Birth rate is greater than death rate. ... Natural decrease occurs when death rate is greater than birth rate. This means that more deaths occur in a population than babies are born so population numbers decline

The population will be doubled by immigration. The correct option is C.

What is immigration?

When an animal settles down in a habitat because it has resources nearby or because it is a good fit for them, this is referred to as immigration.

When an animal emigrates, it's because its habitat is no longer perfect for it and it needs to move to a new location with a better habitat.

It is the quantity of members of the same species that have entered the habitat during the time period under examination from outside the habitat.

To immigrate means to move permanently to another country. To migrate is to move, much like wintertime birds. Depending on the viewpoint, one can either migrate, immigrate, or emigrate.

Immigration can increase the size of a population if the birth and death rates are equal.

Thus, the correct option is C.

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What are the impacts of catastrophic events?
Define global warming? What are the greenhouse gases?
What are the problems associated
arming in artic? Coastal area?
What are some ways that human lifestyles affect the environment?
Describe some sustainable farming techniques.
Describe some environmental parameters that should be examined before building on land?

Answers

Answer:

espero que te sirva

Explanation:

El calentamiento global y el cambio climático tienen coincidencia en la principal

de sus causas, la emisión masiva de los diferentes gases de efecto invernadero o

GEI que retienen el calor dentro de la atmósfera y sobre la superficie terrestre a

través del denominado efecto invernadero.

El efecto invernadero es un proceso natural por el cual se produce la retención

del calor procedente del Sol en la atmósfera terrestre gracias a la capa de GEI que

se encuentra en ella. Estos gases en cantidades normales mantienen la

temperatura del planeta aproximadamente a 33ºC por encima de la que podría

tener si estos no existieran, por lo que el planeta sería demasiado frío para que se

desarrollase vida en él. Sin embargo, actualmente el efecto invernadero se está

volviendo tan intenso a causa de nuestras emisiones que comienza a tener graves

repercusiones en el medio.

El Grupo Intergubernamental de Expertos sobre el Cambio Climático (IPCC)

concluyó en el Quinto Informe de Evaluación (AR5) de 2013 que la influencia

humana había sido la causa dominante de este calentamiento producido desde la

mitad del siglo XX a través de la emisión de GEI, lo cual es una evidencia cada vez

mayor. Entre los principales gases emitidos se encuentran el vapor de agua, el

dióxido de carbono, el metano y el ozono.

13) On Earth, water vapor occurs in the state of matter. a.) Solid Ob.) Liquid C.) Gas d.) Plasma

Answers

Answer:

Gas

Explanation:

Because when we heat water water vapour will come in the gas form

Answer:

The answer is gas

Explanation:

Sorry I don't really know how to explain, when water vapor occurs, the water rise up to the sky in the form of gas.

Hope this will help❤️

Describe the different types of traits that exist.What factors can affect these traits?

Answers

Answer:

Cardinal traits, central traits, and secondary traits.

Explanation:

There are three types of traits according to the Gordon Allport which organized traits into three levels that is cardinal traits, central traits, and secondary traits. Factors that affect these traits are the environmental factors as well as genetic factors. Some of these traits acquire by an individual through inheritance while on the other hand, other traits can get by the people through the exposure to environment that leads to the presence of that traits.

Answer the question and you will get Brainliest :)))))

Answers

(a) troposphere

The atmosphere has five different layers that are determined by the changes in temperature that happen with increasing altitude. Living at the surface of the Earth, we are usually only aware of the events happening in the lowest layer, the troposphere, where all weather occurs

troposphere
Explanation: The troposphere is the lowest layer of the atmosphere and where most clouds are. That means all weather is in the troposphere.

Which phrase describes a feature of clastic sedimentary rocks?
grouped by color
formed by chemical weathering
grouped by size of rock fragments
formed from dead plants and animals

Answers

Answer:

the 2nd one

Explanation:

Answer:

B:formed by chemical weathering

Explanation:

Which process illustrates a feedback mechanism in plants?*
(1) Chloroplasts take in more nitrogen, which increases the rate of photosynthesis.
O
(2) Chloroplasts release more oxygen in response to a decreased rate of
photosynthesis
(3) Guard cells change the size of leaf openings, regulating the exchange of gases.
(4) Guard cells release oxygen from the leaf at night.
Antibody molecules and receptor molecules

Answers

Answer:

The first one is your answer

Chloroplasts take in more nitrogen, which increases the rate of photosynthesis illustrates feedback mechanisms in plants.

feedback mechanism is a form of system regulation that occur in living organs which help to return or restore the body to it's original normal internal condition for sustainability of living. It is also called homeostasis.

Chloroplasts take in more nitrogen, which increases the rate of photosynthesis illustrates feedback mechanisms in plants because nitrogen helps to increase the concentration of chlorophyll which is the green pigment house in chloroplast that aid the increase of photosynthesis rate in plants.

Therefore,Chloroplasts take in more nitrogen, which increases the rate of photosynthesis illustrates feedback mechanisms in plants.

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Does anyone want to get payed good money to do my homework?

Answers

ya i’ll do it for you

The oxygen cycle is closely related to which other cycle?

A. The carbon cycle
B. The nitrogen cycle
C. The phosphorus cycle

Answers

Answer:

A

Explanation:

that what i think

i don't know if I'm right

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m,eet


jtoessthpr​

Answers

everyone

plz do j,oin

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