Assume for the purposes of this problem that the order of and distances between three linked genes are the following: unc-32 10mu vab-7 20mu dpy-17 What is the probability of obtaining a phenotypic unc-32 vab-7 offspring from a cross between a heterozygous fly(unc-32 vab-7 dpy-17/ ) and the triple recessive nematode

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Answer 1

From the distances between genes and their order, it is possible to get recombination frequencies per region (simple and double recombination frequencies). The probability of obtaining a unc-32 vab-7 + offspring is 0.09 = 9%.  

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We are usually asked to get the order of genes in a chromosome. To do so, we need to get the distances between genes. And to get distances between genes, we need to get their recombination frequency.

When three genes are involved, we get the distances by taking the recombination frequency, P, per region.

We talk about regions, R, when we are making reference to the space between two genes.

                Gene 1 -----(R1)----- Gene 2 --------(R2)------ Gene 3

                                    P1                               P2

P1 = recombination frequency between Gene 1 and Gene 2P2 = recombination frequency between Gene 2 and Gene 3

⇒  P1 = (SR + DR) / N

⇒  P2 = (SR + DR)/ N

Where:

SR is the number of simple recombinants in each region, DR is the number of double recombinants in each region, and N is the total number of individuals.

The genetic distance will result from multiplying that frequency by 100 and expressing it in map units (MU). One centiMorgan (cM) equals one map unit (MU).  

In the exposed problem, we need to do the inverse way. We already have the order and distances between genes, and we need to get the recombination frequency, P.

We know that the order of genes is as follows,

unc-32 ------------- vab-7----------------- dpy-17

     

Distances are:

Region 1 = 10 MURegion 2 = 20 MU

We need to get the probability of obtaining a phenotypic unc-32 vab-7 + offspring from a cross between a heter0zyg0us fly (unc-32 vab-7 dpy-17/ + + +  ) and the triple recessive nematode (unc-32 vab-7 dpy-17 / unc-32 vab-7 dpy-17).

Cross:  

unc-32 vab-7 dpy-17 / + + +     x     unc-32 vab-7 dpy-17 / unc-32 vab-7 dpy-17

To get the genotype unc-32 vab-7  + , a simple recombination, SR, must occur in region 2.

So we need to get the simple recombination frequency in Region 2.

To do so, first we need to clear the following equation

Distance between vab-7 dpy-17 = P2 x 100 = 20 MU

20MU = P2 x 100

P2 = 20  / 100

P2 = 0.2

The recombination frequency in region 2 (P2) is 0.2.

Now, we need to get the simple recombination frequency in this region.

P2 = (SR + DR) / N

P2 = Simple recombinants Frequency + Double recombinants Frequency

R1 = 10 MUR2 = 20 MUDouble recombinants Frequency = 10% x 20% = 0.1 x 0.2 = 0.02

P2 = Simple recombinants Frequency + Double recombinants Frequency

0.2 = Simple recombinants Frequency + 0.02

Clearing the equation,

Simple recombinants Frequency = 0.2 - 0.02 = 0.18

Simple recombinant frequency in region 2 will produce the following two chromosomes,

unc-32 vab-7  ++   +   dpy-17

So half of this frequency will produce one chromosome, and the other half will produce the other chromosome.

unc-32 vab-7  +     ⇒   0.09+   +   dpy-17          ⇒   0.09

So, the probability of obtaining a phenotypic unc-32 vab-7 + offspring is 0.09 = 9%.

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Spanish Version:

Viéndolo desde la distancia segura de 230 millones de años luz, los astrónomos dicen en el artículo publicado en The Astrophysical Journal, que este hecho hace que parezca que el agujero negro supermasivo ha sido perturbado. Se desconoce la razón de esto, aunque hay conjeturas.

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¡Con suerte, esto ayudó!

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i did the test

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to
Some
organisms have phenotypes that make them better
increase chances of reproduction.
environment
competitors than others in their
Animals undergo natural selection, but plants and other organisms
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generally do not.
I
Phenotypes found In the most successful members of a species become the most prevalent after
several generations.
M
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Natural selection continues to occur even today

Phenotypes found In the most successful members of a species become the most prevalent after  several generations.

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Mutations are not phenomen that occur because the living being needs it, but rather they are phenomenon that occur at random at any time and determine the possibility of survival.

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