the pharmacogenetic profiling reveals a mutation in a cyp450 enzyme that causes increased enzyme activity. which of the statements below is incorrect? - There are variations in the enzymes as a result of genetic polymorphism
- It would require that the patient with this mutation is given greater than the standard dose of a drug if it is metabolized by this enzyme
- The profiling can be used to predict drug-drug interactions
- The CYP450 variants have no influence on drug metabolism

Answers

Answer 1

The CYP450 variants have no influence on drug metabolism.

How many different CYP450 subtypes exist?

Although there are more than 50 CYP450 enzymes, 90% of medicines are metabolized by CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, & CYP3A5 enzymes.These enzymes are mostly produced in the liver, although they are also found in the kidneys, placenta, lungs, small intestine (where they decrease medication bioavailability), and lungs.

Which CYP450 metabolizes medicines the fastest?

The most prevalently expressed responsible for the conversion enzyme in humans, CYP3A4, is in charge of breaking down more than 120 different drugs. As a result, it is crucial to research enzyme-based drug interactions.

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Related Questions

describe the mass and charge of particles you find in the nucleus and in the electron cloud.

Answers

Proton is the positively charged particle with a charge equivalent to  1.6×10−19C .

Neutron is a neutral charged particle i.e. zero charge.

Electrons are negatively charged particle with a charge equivalent to  −1.6×10−19C .

Protons and Neutrons are inside the nucleus of an atom and contribute to the most of the mass of the atom. Electrons are revolving around the positively charged nucleus in quantized energy shells.

These weeds are growing in a farmer's field. The weeds compete with the soybean plants the farmer grows, so he needs to get rid of them. For a few years, the former relies on manually removing the woods, but that is labor intensive and limits how much crop he can grow. The farmer decided to change his crop to genetically modified soybeans that are herbicide resistant. This allows the farmer to use chemicals to remove the weeds. With this GM soybean, the chemical kills the woods but does not harm the crop. For many years this works, and allows the farmer to expand his farm and grow more soybeans. But then, one of the farmer's fields has a large weed plant remaining after the field has been sprayed with herbicide
1. Which of the following is the likely reason the weed has remained?
a. The weed needed to be resistant in order to survive, so it became resistant
b. A mutation appeared in one weed plant that made that weed not susceptible to the herbicide
2. Which of the following is likely to happen if that weed stays in place?
a. The trait will spread to nearby weeds
b. The weed will survive long enough to reproduce
c. In time, the herbicide will no longer be effective on that field.

Answers

Answer:

1) A mutation appeared in one weed plant that made that weed not   susceptible to the herbicide ( B )

2) The weed will survive long enough to reproduce ( B )

Explanation:

1) The most likely reason the weed remained is :  A mutation appeared in one weed plant that made that weed not susceptible to the herbicide

The weed plant must have undergone some mutation in order to be resistant to the herbicide which would kill the weed before now

2) The most likely thing that will happen if the weed stays in place in that farm is : The weed will survive long enough to reproduce

The trait or mutation of the weed cannot just spread to other weeds nearby it can only spread by reproducing more weeds of same mutation

why do spider bites itch?

Answers

The spider has a venom in their teeth that they inject into your skin when they bite you so you won’t bleed everywhere and your skin has a reaction to the venom because it’s strong enough to have an effect just not strong enough to hurt you.
when they bite and the venom is injected into your skin, the venom is mainly the reason for the itching and pain, this can also cause an allergic reaction

what are some benefits of alternatives to pesticides?

Answers

Answer:

Alternatives to insecticides

Companion planting: planting certain types of plants will keep some pests away. “Soft” chemicals: soap, stinging nettles, and rhubarbs provide excellent alternatives to pesticides. Parasites: certain pests are often easily targeted by specific parasites.

Advantages--No residues, nontoxic to mammals, wildlife, and beneficials. Disadvantages--Can trap both pests and beneficials; some traps are expensive; must be maintained, cleaned, and recoated periodically; effectiveness varies. Advantages--Nontoxic, no residues. Allow water, air, and sunlight to pass through.


Which phrases describe the open-ocean zone? Check all that apply.
very little sunlight
Ofew nutrients
low temperatures
low density
located near coasts

Answers

Answer:

Very Little Sunlight

Few Nutrients

Low temperatures

Explanation:

It was correct on the test.

Hello, t8j5gq6rzt! I hope I can answer your question.

The open-ocean zone has low temperatures because there's little sunlight. So you will want to check:

Very little sunlight

Low temperatures

PS. Brainliest would be appreciated. :)

the illustration below shows a cellular process which of the following is shown in this illustration a gene expression b DNA replication c DNA translation d transcription

Answers

Answer:

dna replication

Explanation:

Answer B

Animals with exoskeleton are called​

Answers

animals that have no bones lol

Answer:

Examples of animals with exoskeletons include insects such as grasshoppers and cockroaches, and crustaceans such as crabs and lobsters, as well as the shells of certain sponges and the various groups of shelled molluscs, including those of snails, clams, tusk shells, chitons and nautilus.

Explanation:

hope this helps     :)

how many milliliters of acetic acid solution (contents of weigh boat C) did you have to add to neutralize the contents of Beaker B, the sodium bicarbonate?

Answers

Answer: SDFGHNJMNJHIBUGVFCVGBJHNK

Explanation:DXGNK MBFCHBJKN

As you are studying for your biology test, your stomach starts to make noises and give you hunger pains. You decide to get up, walk to the kitchen, and get yourself a snack. Explain FULLY and in detail what steps your body systems would be going through during this whole process.

Answers

Explanation:

Digestive system takes place in the stomach and also proteins

The heart is important for transporting oxygen to the muscles when we exercise. How does the heart rate change when we go from sitting on a chair to running up the stairs?
A. The heart rate stops.
B. The heart rate gets slower.
C. The heart rate gets faster.
D. The heart rate stays the same.

Answers

Answer: C. The heart rate gets faster.

Explanation:

its true also give brainliest

The heart rate gets faster

Explanation:

C. Because when you are sitting your heart rate is chill put if you're moving really fast that means your heart rate is going up because you have to deep breaths over and over when you stop running.

How is the instructions for your traits carried on a DNA molecule?
Sequence of the nitrogen bases
In the bond between the phosphate and the sugar
O In the Deoxyribose Sugar
O In the phosphate group

Answers

Sequence of the nitrogen bases

What is the difference between Gene Pool, Genetic Drift and Gene Flow?

Answers

Answer:

Genetic drift is referred to the changes in allele frequency in a gene pool. Gene flow is the process of alleles moving from one population to another.

Explanation:

If the black line represents a reaction without an enzyme and the red line represents the same reaction with the addition of an enzyme, what can be said of the relationship between the use of an enzyme and the energy of the reaction?

A.
Less energy is released by a reaction without an enzyme.
B.
More energy is absorbed by reactions without an enzyme.
C.
More energy is absorbed by a reaction with an enzyme.
D.
Less energy is released by a reaction with an enzyme.

Answers

Answer:

more energy is absorbed by reactions without an enzyme.

Answer:

D.

More energy is absorbed by reactions without an enzyme.

Explanation:

*Please Hurry!*
Which principle tells us that this area has undergone tilting?
a. original horizontality
b. cross-cutting
c. superposition
d. inclusions

Answers

Answer:

A.

Explanation:

original horizontality

describe how the mammalian heart is adapted to it's function

Answers

Answer:

The ventricles are thick walled; to pump blood to the lungs and the rest of the body. The left ventricle has thicker wall to create more pressure because it pumps blood for longer distances round the body; while the right ventricle pumps blood to the lungs close to the heart.

Which phase occurs immediately after a full moon?
waxing gibbous
waning crescent
waning gibbous
waxing crescent

Answers

waning gibbous

youre welcome

What adaptations do trees have in the rainforest?

Question 7 options:

deep roots that do not spread out over a great distance


deep roots and spread their roots out over a great distance


short roots that do not spread out over a great distance.


short roots and spread their roots out over a great distance

Answers

Answer:

the answer is c

Explanation:

i took the quiz and got it right

The adaptations trees have in the rainforest are short roots that do not spread out over a great distance.

How are adaptations necessary in ecology?

All organisms need to adapt to their habitat to be able to survive. This means acclimating to be able to survive the climatic conditions of the ecosystem, predators, and other species that contend for the same food and space.

Thus, the correct option is "C".

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The human body needs minerals to survive. Without
minerals, the body could not function properly. The minerals
that make up rocks are the same minerals that someone
might eat in a bowl of cereal! The body needs about 80
different types of minerals to function properly. Iron enriches
the blood, salt maintains fluid balance, calcium fortifies the
bones, and fluorine strengthens the teeth. Most vital
minerals can be absorbed into the body from eating plants
and lean meats. However, many food manufacturers add
minerals to their products to make them more desirable to
consumers. Eating a balanced diet can ensure that the
proper amount of these essential minerals is ingested.

Question:

The passage tells us that "many food manufacturers add minerals to their products to make them more desirable to consumers." Do you think that this is a good idea? What are the pros and cons?

Answers

Answer:

You have to put down what you think and not what other people thing

Explanation:

You can simply answer this question yourself by doing research or just thinking if its a good idea

Eating vegetables and lean meats can help the body absorb the majority of essential nutrients. However, many food producers add minerals to their products to increase customer appeal.

What are nutrients?

Chemical elements known as nutrients are present in all living things on Earth. They are essential to the survival of all living things, including humans, animals, and plants.

The breakdown of food by nutrients provides energy for living things. They are utilised in every bodily function of an organism.

The majority of vital nutrients can be more easily absorbed by the body when veggies and lean meats are consumed.

To boost consumer appeal, several food companies do, however, add minerals to their products.

Although processing has many advantages, it can also be harmful and reduce the nutritional value of food.

For instance, blanching causes vitamin and mineral leaching losses. Additionally, during processing, milling and extrusion might result in the physical removal of minerals.

Thus, these are some pros and cons of the given scenario.

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How was a round-the-world voyage useful to Darwin for developing his theory of evolution?

Answers

Answer: During the long voyage, Darwin made many observations that helped him form his theory of evolution. For example: He visited tropical rainforests and other new habitats where he saw many plants and animals he had never seen before (see Figure below). This impressed him with the great diversity of life.

Explanation:

What happens in crossing over? Why is it important for sexually reproducing organisms, and what is one of the consequences of errors in crossing over?

Answers

Answer:

Crossing over increases the genetic variation  

Errors in crossover formation result in chromosomal rearrangements (duplications and deletions) and may also cause chromosome nondisjunction

Explanation:

Crossing over, also known as recombination, refers to the exchange of genetic material (DNA) between non-sister chromatids of homologous chromosomes during meiosis. Crossing over increases the genetic variation of the resulting gametes, allowing different genetic combinations to be passed from parents to offspring. Unequal crossing over is a type of error associated with chromosomal duplication and/or deletion events. Unequal crossing over occurs when homologous sequences are not paired precisely. Moreover, errors in crossing over may also cause chromosome nondisjunction, thereby leading to aneuploidies.

Please give me the correct responses.Only answer if you're very good at science/biology.Please don't put links to websites or else I'll report you.

Scientists believe Polar Bears have evolved from a group of Brown Bears that became an isolated population during a time when the Earth's climate began cooling down.What are some adaptations that make Polar Bears different from Brown Bears and what do you think caused the adaptations to occur?​

Answers

Answer:

One adaptation is white fur. There was probably one white cub born to a brown bear mother, and the fur helped camouflage it for safety and later, hunting. This bear would have been more successful in hunting in the arctic, so it was more likely to reproduce and pass on the white fur genes. A second adaptation is the long claws of brown bears that are used for digging through vegetation would have shortened to be safer on ice. Polar bear paws also have little sticky bumps on their paws for gripping ice.

A third adaptation is that polar bears don't hibernate in winter. In winter, there is a lot more food available to them, so they need to stay awake. A fourth adaptation is their hair is also now water repellent, because most of their food comes from the sea. A fifth adaptation is in their digestive system. Polar bears don’t digest carbohydrates as well as brown bears, because their diet has much more fat than anything else. Polar bears hunt seals and can convert the blubber into fat for their bodies to live off of when food is scarce.

What word means "between the dorsal wall and peritoneum” and refers to the location
of the kidneys?

Answers

Answer: The kidneys are situated in between posterior abdominal wall and partial peritoneum.

Explanation:

Kidneys are located at the dorsal side of the body of vertebrates including humans. These are located opposite to the spine. The location of the kidney is the retroperitoneal space that lies in between the posterior abdominal wall and partial peritoneum. Peritoneum is the serous membrane which forms the lining of the abdominal cavity. It also covers the kidneys from the dorsal side. The kidneys are well protected by muscles and fat at the dorsal side.

Type the correct answer in the box.
The temperature equivalent to 77°F is
°C.

Use the formula to convert the temperature.

Answers

Answer:

25 degree celcius

Explanation:

formula

(given degree Fahrenheit - 32)×5÷9

(77 - 32)× 5÷9

= 25°C

Here I will show you how to convert 77 F to C so you know how hot or cold 77 degrees Fahrenheit is in Celsius. The F to C formula is (F − 32) × 5/9 = C. When we enter 77 for F in the formula, we get (77 − 32) × 5/9 = C.

so therefore the answer is 25 degrees celsius

If a wolf eats a herbivore, the energy is transferred ________.

Answers

Explanation:

enrgy used and it will help woth the enery that the herbivore ate

Answer:

from the herbivore to the wolf

Energy extraction and the complete oxidation of foodstuffs requires three stages. The energy extracted from fuels is converted to ATP. Select the statements that are true for the different stages required for energy extraction and complete oxidation of foodstuffs.
A. In the first stage, macromolecules are converted to monomers, and a small amount of ATP is produced.
B. In the first and second stages the majority of ATP needed for cellular processes is produced.
C. In the third stage, fuel molecules are completely oxidized to CO2 , and most of the ATP needed for cellular processes is produced.
D. In the third stage, fuel molecules are completely oxidized to CO2 , and a small amount of ATP is produced.
E. In the second stage, monomers are broken down, and a small amount of ATP is produced.
F. In the third stage, fuel molecules are completely oxidized to CO2 , and no ATP is produced.

Answers

Answer:

C. In the third stage, fuel molecules are completely oxidized to CO2 , and most of the ATP needed for cellular processes is produced.

Explanation:

The three stages in the generation of energy from the oxidation of foodstuffs are given below:

First stage - This stage is the preparation stage and no useful energy is produced in this stage. In this stage, large molecules in food are broken down into smaller units. Proteins are broken down to amino acids, polysaccharides to simple sugars such as glucose, and fats are broken down to glycerol and fatty acids.

Second stage - In this stage, the various small molecules from the first stage are degraded to simple units (mostly acetyl-CoA) that are useful in metabolic activities of the body. Few ATP molecules are generated in this stage.

Third stage - In this final stage, most of the ATP required for cellular processes is produced from the complete oxidation of the acetyl unit of acetyl CoA to CO₂ in the citric acid cycle as well the oxidation of the electron carriers NADH and FADH₂ in oxidative phosphorylation.

Match each explanation to the correct step of the Scientific
Method.​

Answers

Explanation:

Hi!! sorry to take up this space and probably waste your time but you didn't insert a picture or equation!! I'm so sorry, I'd help you otherwise!

Pls answer fast!!!! Timed!!!
Which of these descriptions best contrasts safety knowledge for cows and horses?
A. Horses have a definite flight zone, whereas cows do not
B. Cows will startle at sudden movement or noise, but horses do not.
C. Cows have a definite flight zone, whereas horses do not.
D. Cows have 360-degree vision, but horses do not​

Answers

Answer:

Cows have a definite flight zone, whereas horses do not. So the answer is C.

True or False: The larval stage of the sea urchin is called the pluteus.

Answers

Answer:

False

Explanation:

it is called planktotrophs.

Answer:

larva, which is called a pluteus, has a small, wartlike bud that grows into the adult while the pluteus tissue disintegrates. In both examples it is as if the organism has two life histories, one built on the ruins of another.

Explanation:

hope this helps   :)

Organisms that live in similar environments, such as the ocean, often have similar adaptations. This is often due to

A. convergent evolution
B. coevolution Proton
C. gradualism
D. sexual selection ​

Answers

Answer:

 A.

Explanation:

Convergent evolution is the independent evolution of similar features in species of different periods or epochs in time.

Organisms that live in similar environments, such as the ocean, often have similar adaptations, and this is often due to convergent evolution, which is in Option A, as convergent evolution is a process by which organisms that live in similar environments adapt.

What are coevolution and convergent evolution?

Convergent evolution occurs because the same selective pressures are acting on the organisms, leading to the development of similar adaptations, such as streamlined bodies and fins, in many species of fish that live in the ocean and this is due to convergent evolution.

Hence, organisms that live in similar environments, such as the ocean, often have similar adaptations, and this is often due to convergent evolution, which is in Option A, as convergent evolution is a process by which organisms that live in similar environments adapt.

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HELPPPPPPPP!!!! what is a mutation that a polar bear can have to help conserve energy and how do genetic mutations relate to chromosomes, genes, protein, and DNA?

Answers

Answer:

wings

Explanation:

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