The site within a chromosome where dna replication begins is known as the of replication.

Answers

Answer 1

At specific sites, referred to as origins, wherever DNA replication starts, the double helix of DNA unwinds.

What transpires when DNA replication occurs?

Through process of DNA replication, the double DNA molecule is reproduced to produce two identical genetic molecules. Replication is a vital process because every when a cell divides, the two additional clones must share the very same genetic information, or DNA, as the parent cell.

What part of the cell does DNA replication occur in?

DNA replication occurs in the nuclei of eukaryotic cells and the nucleoid sections of prokaryotic cells. Eukaryotic cells, which have a nucleus and organelles that are bound to membranes, include animal and plant cells. Eukaryotic cells contain their DNA in their nuclei.

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Related Questions

A newly developed insecticide compound steals high-energy electrons from fadh2 and nadh before they can bind to the electron transport chain. Why does this kill insects?.

Answers

A newly developed insecticide compound steals high-energy electrons from fadh2 and NADH before they can bind to the electron transport chain. Fermentation pathways will be switched on, supplying insufficient ATP to maintain the insect.

They encompass such chemical substances as hydrogen cyanide, naphthalene, nicotine, and methyl bromide and are used in particular for insect pests of stored products or for fumigating nursery inventory.

Insecticides are chemicals used to bugs. a few insecticides also are to human beings. Many pesticides can purpose poisoning after being swallowed, inhaled, or absorbed thru the pores and skin. signs can also encompass eye tearing, coughing, heart problems, and breathing difficulties.

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Mitosis can occur in both haploid and diploid cells, but meiosis cannot occur in haploid cells. Why not?.

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Meiosis can not occur in haploid cell because  the chromosome number gets halved in meiosis.

What is mitosis?

Mitosis is a stage of the cell cycle during which replicated chromosomes are separated into two new nuclei. Mitosis results in the formation of genetically identical cells with the same number of chromosomes. As a result, mitosis is also referred to as equational division.

Mitosis can occur in a haploid cell because the cell remains haploid at the end of mitosis. The haploid cell will have half the haploid number of chromosomes at the end of meiosis. Meiosis is a process that occurs in germline cells that produce gametes (sperm and eggs).

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what is the function of the radius?



-Science

Answers

It’s functions are to articulate with the ulna & humerus at the elbow to provide supination and pronation then to articulate with the lunate and scaphoid to provide all the movements of the wrist.

The greater the temperature difference between two temperature reservoirs, the more ________ can be done.

Answers

The greater the temperature difference between two temperature reservoirs, the more the greater the efficiency  can be done.

A thermal reservoir, also thermal power reservoir or thermal bath, is a thermodynamic machine with a heat ability so large that the temperature of the reservoir modifications fantastically little while a far greater massive quantity of heat is brought or extracted.

In actual thermodynamic structures, expansive bodies of water which include oceans, lakes or rivers are taken into consideration thermal strength reservoirs because of their huge masses and high warmness capacities. The environment is also considered a thermal power reservoir.

Temperature is one of the thermodynamic houses of fluids that determines the kingdom of hotness or coldness of it. Temperature is measured in both Kelvin or Celsius or Fahrenheit. Kelvin is the most commonplace one that is used because of its independence from the houses of the substance.

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In cross section, the __________ matter of the spinal cord looks like a butterfly or the letter h.

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In cross section, the gray matter of the spinal cord looks like a butterfly or the letter H.

Gray matter is the outermost layer of the brain and spinal cord that comprises of unmyelinated neurons and some other cells of the nervous system. The function of gray matter is in processing information. It also enables individuals to control movement, memory, and emotions.

Spinal cord is the backbone of the vertebrate organisms. In humans, it is composed of 5 types of bones that extend from the base of the brain to the hip region. The 5 types of bones are cervical spine (C1-C7), thoracic spine (T1-T12), lumbar spine (L1-L5), sacral spine (S1-S5), and a tail bone, that make up a total of 33 bones.

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An organism’s traits are determined by the specific combination of inherited _____.

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The precise mix of inherited genes determines the particular trait of an organism.

What factors determine an organism's characteristics?

Traits may be influenced by genes, the environment, or a mixture of the two. Eye colour is an example of a qualitative feature that may also be quantified (such as height or blood pressure). A specific attribute is part of an individual's overall phenotype.

What characteristics of organisms are influenced by a certain inheritance pattern?

The genotype of an organism within a single organism is the particular set of alleles for that gene, and (as was already mentioned) the physical characteristic linked to that genotype is referred to as the organism's phenotype.

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the major cation in extracellular fluid is

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Answer:

Sodium is the major cation found in intracellular fluid.

escribe what happens during gene mutation

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Genetic mutation is a change to a gene's DNA sequence to produce something different. It creates a permanent change to that gene's DNA sequence. These variations help us to evolve and can change per person and through generations to come.

Hope this helps:)

Plasmids often have antibiotic resistance genes. How do scientists take advantage of the antibiotic resistance genes in the lab?.

Answers

Scientists take the advantage of plasmids having antibiotic resistance gene by using them as a vectors to clone, transfer and manipulate genes and also detecting the growth of such plasmids in selective media.

Plasmids are the extrachromosomal DNA present in bacterial cells. These are circular double stranded DNA molecules that can replicate on their own. Plasmids are known to exist in some archaea and eukaryotes as well. Usually consisting of DNA, some species are known to contain RNA as genetic material as well.

Vectors in laboratories are the agents that are used to transfer the gene of interest into the desired host cell. Vectors can be of two types: cloning vectors and expression vectors.

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Describe what happens in anaphase, include a picture of the process.

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During anaphase, each pair of chromosomes is separated into two identical, independent chromosomes. The chromosomes are separated by a structure called the mitotic spindle.

Anaphase is the third stage of Mitosis or cell division (karyokinesis). During this phase, the sister chromatids separate from each other and are pulled together opposite ends for the formation of daughter nuclei.

What is Anaphase?

During the cell cycle, the actual cell division takes places in the M-phase. This M-phase is called Mitotic or Meiotic phase. Cell division occurs in cell by two processes which are Mitosis and Meiosis.

Anaphase is the third phase of mitosis, during this process the separation of the duplicated genetic material is carried out in the nucleus of a parent cell into two identical daughter cells.

In anaphase stage, the sister chromatids separate out from each other and are pulled towards opposite ends of the parent cell. The protein which holds together the sister chromatids is broken down, this allows them to separate from each other. Each chromatid is now converted into chromosome. The chromosomes of each pair are pulled towards opposite ends of the cell to form the new duaghter cells.

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Eukaryotic chromosomes tend to be much larger than prokaryotic chromosomes. In order to package these large chromosomes into the nucleus, which family of proteins are used by the cell?(1 point).

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In order to package these large chromosomes into the nucleus Histone proteins is used by the cell .

Eukaryotic chromosomes are places inside the nucleus, whereas prokaryotic chromosomes are inside the nucleoid. Eukaryotic cells looks larger than prokaryotic cells because eukaryotic cells have a nuclear membrane and membrane bound organelles.

Eukaryotic cells are bigger in size than that of prokaryotic cells because of the compartment structure. Eukaryotic cells contain different membrane-bound structures termed as organelles, that carries out different functions within the cell.

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Can someone find all of the amino acid structures in the chain pictured at the top right please this is urgent.

Answers

The amino acids present in the peptide structure are:

leucinecysteinetyrosine, andglutamic acid

What are amino acids?

Amino acids are organic compounds that form the building blocks of the macromolecular structures called proteins.

Amino acids are liked to each other by peptide bonds to form the primary structure of proteins.

Peptide bonds are formed between the carboxy-terminal of one amino acid and the N-terminal of another amino acid. A water molecule is removed when peptide bonds are formed between two amino acids.

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armed with the information that chromatin coated beads can generate mitotic spindles in xenopus egg extracts, you decide to try to generate spindles using beads coated with proteins instead

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Armed with the information that chromatin coated beads can generate mitotic spindles in xenopus egg extracts, to try to generate spindles using beads coated with proteins instead beads coated with active ran .

The mitotic spindle is a structure that bureaucracy at some stage in mobile department and separates duplicated chromosomes. In eukaryotic cells, the mitotic equipment consists of  centrosomes and spindle microtubules (discern 43.nine). The centrosome is 1–2 μm in diameter.

The mitotic spindles migrate to contrary poles of the elongated mobile to help chromosomes align on the valuable equator of the cell, known as the metaphase plate. in the end, these mitotic spindle fibers move backward and forward and shorten to assist the duplicated chromosomes separate and migrate to the opposite poles.

The spindle formation begins during the prophase. at some stage in the prophase, the movement of centromeres closer to the two ends effects in the formation of tube-like systems referred to as the spindle fibers. these get assembled among the centromeres and the poles.

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tamoxifen is a drug that is used to treat breast cancer. it inhibits the activities of theestrogen receptor in breast epithelial cells, which are the cells that are relevant to breast cancer. one of the concerns that scientists had during the development of tamoxifen as a therapy for breast cancer was that other cell types require estrogen signaling for their function. for example, it is known that cells in bone tissue require estrogen signaling. as a result, there was a concern that use of tamoxifen would lead to bone loss in patients. in reality, however, researchers were surprised to find that tamoxifen actually led to an increase in bone density in breast cancer patients. at the same time, tamoxifen did inhibit the activity of the estrogen receptor in breast epithelial cells in these patients. what is the best explanation for this finding?

Answers

Tamoxifen is a hormone inhibitor that works by preventing the body from producing estrogen, a hormone that premenopausal and postmenopausal women have in their bodies.

Tamoxifen competes with other chemicals to bind to the estrogen receptor protein's active site, making it a competitive inhibitor. It thus inhibits the release of estrogen. You went on to say that the process is irreversible because when tamoxifen attaches to the receptor, the protein is irreversibly eliminated.

Tamoxifen is a member of the medication group known as selective estrogen receptor modulators. It generally works by preventing estrogen's effects on breast tissue, which can lead to breast cancer or worsen cases where cancer has already started. Tamoxifen is administered to stop the growth of cancer cells.

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The trend for women to delay childbirth until their late 20s or early 30s has ___________ while the peak years for female fertility are ____________.

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The trend for women to delay childbirth until their late 20s or early 30s has continued while the peak years for female fertility are late adolescence and early adulthood.

Female fertility refers to a woman's ability to bear biological children. Female fertility is affected by age and is a major factor in female fertility. Fertility in women peaks between her late teens and late twenties, after which it gradually declines. Ovulation typically occurs 14 days before the start of the next menstrual period in a 28-day menstrual cycle.

The reproductive years of a woman are between her late teens and late twenties. Fertility (the ability to become pregnant) begins to decline around the age of 30. This decline accelerates once you reach your mid-30s. By the age of 45, fertility has declined to the point where most women will be unable to conceive naturally.

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A life cycle in which the only multicellular form is haploid is most typical of __________.

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A life cycle in which the only multicellular form is haploid is most typical of  Fungi.

Many fungi have life structure in which the multicellular body of the organism is haploid. The process of sexual reproduction, specialized haploid cells from a diploid zygote.

life cycle of fungi are considered to have many stages .They have four-stage life cycle spore, germ, hypha, mature mycelium.  Plants mostly have multicellular haploid and multicellular diploid stages of life cycle . Fertilization is responsible for multicellular diploid sporophyte, that produces haploid spores via meiosis.

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Which amino acid chain will be formed by the codons shown below?

Answers

Answer:

I will tell you when i know

Explanation:

What kind of nutrient should be consumed the night before or several hours before aerobic activity? Why?

No links or files! I will report!

Answers

The kind of nutrient that should be consumed the night before or several hours before the aerobic activity is complex carbohydrates.

What are complex carbohydrates?

Complex carbohydrates are a special class of carbohydrate molecule that is generated by the union of simple carbohydrates through glycosidic bonds, which include for example starch and serves as long term storage of energy for aerobic exercise.

Therefore, with this data, we can see that the complex carbohydrates must be consumed 2 o 3 hours before aerobic activity because this type of nutrient functions as a storage of energy.

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The cell type that is responsible for maintaining bone once it has been formed is the ______.

a. osteoclast
b. osteoblast
c. chondrocyte
d. osteocyte
e. chondroblast

Answers

Answer: Osteoblasts B is the correct answer

Explanation:

Osteoblasts are the bone cells that are primarily responsible for synthesizing bone matrix proteins and minerals during early bone formation in the embryo

The fact that genetic codon is universal indicates that all living organisms are.

Answers

The fact that genetic codon is universal indicates that all living organisms are : evolutionarily related.

What do you mean by genetic codons is universal?

The genetic code is universal because all known living organisms use the same genetic code. This clearly shows that all organisms share a common evolutionary history and  genetic code is unambiguous.

Genetic code consists of sequence of bases in DNA or RNA. Groups of three bases form codons where each codon stands for one amino acid.

The universal triple-nucleotide genetic code that allows DNA-encoded mRNA to be translated into amino acid sequences of proteins using tRNA and many modification factors, that is essentially common to all living organisms on Earth.

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You are studying a drug that blocks translation in bacteria. You want to know more about its mechanism of action. You treat bacteria with the drug and isolate mrnas with their associated proteins from the treated bacteria. In bacteria treated with the drug, you find that small ribosomal subunits are bound to the mrnas, but not the large subunits. In which stage does this drug arrest translation?.

Answers

In bacteria treated with the drug, you find that small ribosomal subunits are bound to the mRNAs, but not the large subunits. This drug arrest translation in the termination stage.

The natural compound Blasticidin S, which acts on both prokaryotic and eukaryotic cells and inhibits both peptidyl-tRNA hydrolysis and to a lesser extent peptide bond formation, is the only known small molecule inhibitor that impacts termination.

However, this medication binds to the ribosomal 50S subunit at a place shared with several other antibiotics and functions primarily as a PTC inhibitor that has been demonstrated to deform the CCA end of the P-site tRNA8. Therefore, interference is its way of action.

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I lied lol... I'll add more points for these 2 :)

Answers

Answer:

1st Picture B, The air cools until it reaches the dewpoint.

2nd picture is,  B. The air temperature is closer to the dewpoint, making cloud formation more likely.

Explanation: Hope this helps!

1st Picture B, The air cools until it reaches the dewpoint.
2nd picture is, B. The air temperature is closer to the dewpoint, making cloud formation more likely.

Based on replication proteins, DNA replication in archaea is most similar to that of
a) eukaryotes
b) bacteria

Answers

The archaeal DNA replication machinery bears a striking resemblance to that of eukaryotes and is distinctly different from the bacterial apparatus.

How is archaea DNA similar to eukaryotic DNA?

Archaea cell membranes are composed of isoprenoid-based glycerol lipids. It does not have murein in its cell wall and its position is replaced by a certain protein. The DNA polymerase enzymes that copy DNA to form RNA are different from bacteria. Proteins in DNA replication are more like eukaryotes than they are homologous bacteria. Another distinctive feature is that Archaea are insensitive to most antibiotics that have the potential to inhibit bacteria or eukaryotes.

The cell wall of Archaea differs from Gram-positive and Gram-negative which are the common types of cell walls of bacteria. Cell walls composed of murein are never found in Archaea. Instead, the cell wall is always composed of layers of S which are protein subunits arranged regularly on the cell surface.

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A new organism has been discovered! It was discovered inside a chicken's intestines, in Washington
state! In examining the organism under a microscope, scientists found that it is a single-celled organism that
consumes tiny bacteria. Upon studying it further, scientists also observed that this organism does not have a
nucleus.
These scientists are working to classify this organism. What Kingdom would you recommend they classify this
organism into and why?

Answers

Answer: Bacteria because its single celled and it can only be seen through a microscope

Explanation: that's all i know

The ph of the inner thylakoid space, the stroma, and the cytosol of a particular plant cell has been measured. Which, if any, relationship would you expect to find?.

Answers

The relation between the ph of the thykakoid and the stroma is that the ph of thylakoid is lower than that of the stroma.

The ph of the thylakoid membrane is 8 under normal circumstances, but during photosynthesis it became extremely acidic, like 4. During the light reaction of photosynthesis, the electron transport chain uses the energy supplied by excited electrons to pump H+ ions from the stroma to the lumen of the thylakoid membrane. Both the stroma and the thylakoid membranes contain H+ ions. This proves that the ph of lumen of the thykakoid membrane is lower than the stroma.

We are aware that lumen has a large concentration of H+ ions and that the pH will be lower the more H+ ions there are. While plants often maintain an acidic pH in the stroma to increase the concentration and potential difference of H+ ions for ATP synthesis.

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which statement about coenzymes is false? some enzymes require a coenzyme to carry out their function or activity. a coenzyme attaches to the enzyme to form an active complex. coenzymes are a part of the enzyme structure. all b vitamins function as coenzymes.

Answers

Coenzymes are a part of the enzyme structure is the false statement here

A coenzyme is defined as an organic molecule that binds to the active site of a specific enzyme and helps catalyze a reaction. In particular, coenzymes can act as electron carriers in these reactions or transfer between enzymes as functional groups. Coenzymes are organic compounds necessary for the catalytic activity of many enzymes. They are the often vitamins or the derivatives of vitamins. It can act as a catalyst without an enzyme, but it is not as effective as when combined with an enzyme. Examples of the coenzymes: Nicotinamide Adenine Dinucleotide (NAD), the Nicotinamide Adenine the Dinucleotide Phosphate (NADP) and the Flavin Adenine Dinucleotide (FAD)

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Which environmental agency found itself under investigation after it
was discovered that it was making mutually beneficial agreements
with environmental polluters?

A-Environmental Protection Agency
B-U.S. Department of Agriculture
C-World Wildlife Fund

Answers

Environmental Protection Agency- found itself under investigation after it was discovered that it was making mutually beneficial agreements with environmental polluters.

What is Environmental Protection Agency?

President Richard Nixon issued an executive order in December 1970 creating the Environmental Protection Agency (EPA). The goal of this federal government organisation is to safeguard both human and environmental health. The EPA, which has its main office in Washington, D.C., is in charge of developing laws and standards that advance both public and environmental health.

Cosian bargaining theorem applies to EPA. The theorem states that polluter and victim can reach a mutually beneficial bargain if the damage from pollution is higher than the polluter’s net return from the sale of the good generating the pollutants.

Hence the correct option is A; Environmental Protection Agency

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a botanist hypothesizes that as flowers evolved tubular corollas, their nectar attracted a particular species of long-tongued fly that became their only insect pollinator. for this hypothesis to be reasonable, what issue should the botanist address?

Answers

One who researches 'botany' is called a 'botanist'. Botany is one of the world's oldest natural sciences. initially, Botany protected all plant-like organisms inclusive of algae, lichens, ferns, fungi, and mosses in conjunction with actual flowers.

Darwin understood the centrality of development in a deep and profoundly vital manner, both for animals and for flora. His notebooks document his cautious studying and interest in animal embryology and plant leaf and floral organ morphogenesis.

Butterfly-pollinated plants usually have pretty flashy flowers in hues like crimson and purple. these plants do not have the quantity of pollen that bee-attracting flowers do, however they've huge components of nectar to feed the butterflies.

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Which of the following substances has been banned as an ergogenic ald by a national athletic association in the United States? Check all that apply Check Al That Apply A. Anabolic steroids B. Growth hormone C. Branched-chain amino acids D. Creatine E. Beetroot juice

Answers

Anabolic steroids substances has been banned as an ergogenic ald by a national athletic association in the United States.

What are anabolic steroids?

Anabolic steroids are class C medications that require a prescription and can only be distributed by pharmacists.

Having anabolic steroids for personal use is acceptable. As long as it's done in person, they can also be imported or exported. Therefore, they cannot be sent over the mail or delivered by a courier or freight company.

If you're suspected of distributing or selling anabolic steroids, it's against the law to possess, import, or export them. They can also be given to friends. The punishment is an infinite fine or potentially a 14-year prison term.

Therefore, Anabolic steroids substances has been banned as an ergogenic ald by a national athletic association in the United States.

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what combination do big agricultural farms want to produce alot of crops without having to manually remove weeds? what combination do big agricultural farms want to produce alot of crops without having to manually remove weeds? weeds that are resistant to glyphosphate and crops that are not resistant.

Answers

Big agricultural farms want to produce a lot of crops without having to manually remove weeds by using the combination of "weeds that are resistant to glyphosphate and crops that are not resistant."

What is agriculture?

Agriculture, sometimes known as farming, is the cultivation of plants and cattle. Agriculture was an important step in the growth of sedentary human civilization, since it produced food surpluses that allowed people to live in cities. Agriculture has been around for thousands of years. Agriculture is classified into four types: shifting cultivation, subsistence farming, pastoralism, and intensive farming. Agriculture is the practice of cultivating soil, growing crops, and rearing livestock. It entails preparing plant and animal items for human use and distributing them to marketplaces.

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Four integers have a mean of 14, a median of 14, a mode of 14 and a range of 4.Find the four integer. Select the correct answer from the 1,2,3,4..... SOS PLEASE HELP PLEASEEEEEWhich sentence is the best to add to the end of the second paragraph? Folk Art in America Folk art, unlike fine art, is usually created by ordinary people for ordinary people. Paintings are a common form of folk art. They have been created in many countries for hundreds of years. In the United States, modern folk artists mostly worked in the Northeast, in Pennsylvania, New York, and New England. Some American folk painters earned a living by painting commercial signs. The signs over shop doors told people what each shop sold. For example, a bakery usually had a painting of a freshly baked loaf of bread. /\ |1. Portrait paintings were the most common form of American folk art. 2. These signs were bright, colorful, and made passers-by want to stop or call3. Folk paintings are always pleasing to look at because they are so clear and simple.4. Some paintings showed animals and buildings standing on top of each other or people toppling over. Many folk painters traveled from place to place, creating art where they went. They would paint portraits of people who would pay them to do so. Folk artists also painted scenes of farms, mountains, meadows, and even ships and ports. These artists focused more on the decorative use of the art rather than the technique of making the art. This was what made folk paintings special. one advantage of a exchange rate system is that the country with such a system is less affected by inflation in other countries Given the data in the table, what is the average atomic mass of chlorine? chlorine-35 chlorine-37 atomic mass 34. 969 amu 36. 966 amu r dative abundance 75. 78 percent 24. 22 percent a. 34. 969 amu b. 35. 453 amu c. 35. 9675 amu d. 36. 966 amu. appendicitis and poisoning are examples of: The integer 2019 can be formed by placing two consecutive two-digit positive integers, 19 and 20, in decreasing order. Another example is 3534 (35,34). What is the sum of all four-digit positive integers greater 2019 can be formed in this way?(A)476,681 (B)476,861 (C)478,661 (D)468,671 (E)468,761 Write an inequality to match the situation. Use T for the variable.The temperature in a refrigerator truck must be kept at or below 38 degrees Fahrenheit. Please help me I will give you brainiest, pleasex + 9 = 133x = 12x + 5 9 = 02x + 5 = 175x 3 = 17x 3 = 17x = 35[tex]\frac{4x}{4} =4[/tex]3( x + 4) = 158 + x 5 = 7 Do you believe in regrets why or why not which client would the nurse recognize as having the greatest risk for complications during the intraoperative or postoperative period? ___ reading is ideal and helps comprehension. : crispr-cas9 may be used as a gene-editing tool to repair mutant genes (such as the gene that causes huntington's disease in humans). this technique has been used in bacteria, mice, and even human embryos. first, crispr-cas9 is used to target and remove the mutant gene. second, naturally occurring repair enzymes will add the wild-type gene into the gap left from the site where the mutant gene was removed. which of these bacterial repair mechanisms would most likely be responsible for repairing the dna when used to edit bacterial genes? choose one: a. nucleotide excision b. methyl mismatch repair c. base excision d. umudc translesion bypass synthesis in sos e. reca recombination repair NEED to know today PLSS.Game Station 4: Spinner of 4 equal parts: Red, Purple, Green and Orange - Rules: If the arrow lands in the red quadrant, "Team Y" gets 7 points. If it lands in the other quadrants, both teams lose 1 pointA. "Team Y" spins 5 times. How many of the possible outcomes could have landed in Red exactly 3 times and on purple exactly 2 times?B. "Team Z" spins 4 times. How many of the possible outcomes could have landed in RedC. "Team Y" spins 5 times. How many of the possible outcomes could have landed in Red at least once?use combinations, not probability. A 2300-kg car slows down at a rate of 3. 0 m/s2 when approaching a stop sign. What is the magnitude of the net force causing it to slow down?. Does anyone know how to solve this? My assignment is due soon. It is about transversals of parallel lines: solve for x. ross has received a special order for 10,000 units of its product at a special price of $30. the product normally sells for $40 and has the following manufacturing costs: Can I get the answer and explanation to attached question please? Some clues left on a drive that might indicate steganography include which of the following?a. Graphics files with the same name but different file sizesb. Multiple copies of a graphics filec. Steganography programs in the suspect's All Programs listD. All of the above which of the following does not describe a metal? question 24 options: a) good conductor of electricity b) good conductor of heat c) found on the left side of the periodic table d) tends to gain electrons e) forms ionic compounds with nonmetals can someone really SMART help me