Why would mutation of a tyrosine residue to glutamate in the intracellular portion of a growth factor receptor lead to increased tumor formation

Answers

Answer 1

Answer:

this mutation leads to a constitutively active state where the receptor can not be inactivated by dephosphorylation  

Explanation:

Phosphorylation is a posttranslational modification that usually occurs at the side chains of serine, tyrosine and threonine residues, thereby regulating protein function. Phosphomimetic amino acids are substitutions (mutations) able to mimic the phosphorylated form of the protein, resulting in constitutive activation/inactivation of the corresponding protein. In this case, it is expected that the substitution of tyrosine to glutamate gives rise to a constitutively active state of the receptor by replacing tyrosine with a phosphomimetic residue.


Related Questions

if something is burned a reaction has occurred

Answers

Answer:

true

Explanation:

When the reactants are heated, the average kinetic energy of the molecules increases. This means that more molecules are moving faster and hitting each other with more energy.

HOPE IT HELPS

Answer:

Combustion reaction

Shenya Jones, a 34-year-old female, arrives at the office with a swelling and a red pustule on her face. She states the problem started two days ago as a small pimple near her nose. It became irritated then became extremely swollen and painful overnight. This morning there was yellow drainage noted at the site and the swelling has increased. The area of drainage is approximately 1 cm in diameter. The upper lip, side of the face, and nose are all swollen. She rates the pain in her face as a 7 out of 10. The physician thinks the condition may be impetigo or methicillin-resistant Staphylococcus aureus (MRSA), a type of skin infection that is resistant to the common antibiotics used to treat it. A wound culture is obtained.


1. Considering the structures of the skin, what most likely was the cause of the original pimple on this patient's skin?

2. How could Shenya have prevented this skin infection?
Can someone help me please i will pay i have to do this by 12am today no later than that

Answers

1. a sebaceous gland, the types of glands that secrete the oils that keep your skin healthy, likely became a bit clogged and infected. this could have happened for any number of reasons, such as an excess of oil production due to hormones, or buildups of oil due to makeup or improper cleaning.
2. she could have prevented it by not touching the pimple and letting it heal on its own, instead of aggravating the small initial infection. she also could have cleaned her face every morning and night and worn light facial makeup, if any.

All of the following are true of spermatogenesis EXCEPT: Question 4 options: One spermatogonium produces 4 spermatids Genetically diverse spermatids are created. The products are spermatozoa that each have a head, midpiece and tail. DNA replicates once, but cells divide twice. Spermatids containing 23 chromosomes (1n) are produced.

Answers

Answer: The products are spermatozoa that each have a head, midpiece and tail.

Explanation:

The spermatogenesis can be defined as the process of gamete production in human males. It takes place in the testes in males. In this process the spermatids are produced which are four in number through reductional cell division called as meiosis. Each spermatid is haploid in number and the genetic material present in each is diverse as a result siblings are not identical to each other. The spermatozoa is an immature sperm cell which develops head, middle piece and tail. But it is not a precursor of production of sperm cells via cell division.

The health department is responsible to make sure there are written directions for critical control point procedures.
True
False

Answers

Answer:

I think it's true...

Explanation:

Answer:

True

Explanation:

edge2021

what is the answer to 9 i’m not sure if i have it right?

Answers

I think you got it right
But I’m but sure

Answer:

answer - C

Explanation:

i think the answer is - C

Which situation is a result of crossing-over during meiosis?
A
Genes are duplicated exactly, ensuring that offspring will be
identical to the parents.
B
Chromatids thicken and align themselves, helping to ensure
genetic continuity.
с
Genes are rearranged, increasing the variability of offspring.
D
Chromatids fail to sort independently, creating abnormal
chromosome numbers.

Answers

Answer:

C

Explanation: Genes are rearranged due to crossing over and offspring can vary in traits and appearance

1. What is the most important mutation that led to human life? ​

Answers

Answer:The ultimate source of all genetic variation is mutation. Mutation is important as the first step of evolution because it creates a new DNA sequence for a particular gene, creating a new allele. Recombination also can create a new DNA sequence (a new allele) for a specific gene through intragenic recombination.

Explanation:


Cells are open systems that exchange matter and energy with their surroundings. Which of the following best explains
why plant cells require sunlight to make organic compounds, according to Gibbs's theory of free energy?
O The photosynthetic reaction releases free energy to the surroundings.
O The photosynthetic reaction's free energy is in equilibrium.
The reactants of photosynthesis have less free energy than the products,
The change in free energy (AG) of the photosynthetic system is less than zero.

Answers

Answer:

I'm not sure if this is correct but I think it's C

Answer:

C ( I think)

Explanation:

If a chemical reaction requires an energy input rather than releasing energy, then the ∆G for that reaction will be a positive value. In this case, the products have more free energy than the reactants. Thus, we can think of the reactions’ products as energy-storing molecules. We call these chemical reactions endergonic reactions, and they are non-spontaneous. An endergonic reaction will not take place on its own without adding free energy.


PLSS HELP! Earths layers are crust,____ and _____ (inner and outer)

Answers

Answer:

mantle and core.

Explanation:

core has two divisions

inner core

outer core

Starting at the center, Earth is composed of four distinct layers. They are, from deepest to shallowest, the inner core, the outer core, the mantle and the crust.

PLEASE HELP I WILL MARK BRAINLIEST. Listed in the Item bank are key terms and expressions, each of which is associated with one of the columns. Some terms may display additional information when you click on them. Drag and drop each item into correct column. Order does not matter. PLEASE HELP

Answers

Producer: Grass, trees, algae

Consumer: Birds, cows, humans

Decomposer: Earthworms, fungi, mushrooms

Answer:

Producer: Grass, trees, algae

Consumer: Birds, cows, humans

Decomposer: Earthworms, fungi, mushrooms

Explanation:

Hope This Helps!

Please Mark Me Brainly!

which of the following statements describes the role water plays in a rain storm

Answers

Answer: D. All of the above.

Explanation:

Which of the following is NOT an external structure of insects?
Head
Larva
Thorax
Abdomen

Answers

Answer: larva.......

Journal
1. The following are the functions of the skeletal system, except
a. It gives shape to the body
b. It serves as the framework of the body.
c. It protects the internal organ of the body.
d. It circulates oxygen and removes carbon dioxide.
2. Why is bone marrow important to the body?
a. It stores much fat.
b. It makes the bone strong.
c. It produces red blood cell.
d. It produces new bone cell.​

Answers

Answer:

1.

Answer: D

2.

Answer: A,C,D

A gene can have many alleles. Why is it that any given person only carries two copies of each allele

Answers

Since diploid organisms have two copies of each chromosome, they have two of each gene. Since genes come in more than one version, an organism can have two of the same alleles of a gene, or two different alleles. This is important because alleles can be dominant, recessive, or codominant to each other.

How does increasing plant biomass (amount of plants) affect atmospheric CO

Answers

Answer:

Since there are more plants more carbon dioxide is being removed because plants are carbon reservoirs.

Explanation:

An investigator wishes to use animals in an experiment that involves category B, C, and D activities performed on the same animal. How should the animal be categorized

Answers

Answer:

Category D

Explanation:

In the USA, the Federal Animal Welfare Regulations require that research laboratories report animal use according to the species as well as the number of individuals subject to experimentation procedures. Moreover, animal use for research/teaching purposes is also reported according to the classification by pain and distress categories. Basically, this classification has four categories (B,C, D and E) in increasing order according to the pain level suffered by research animals. Animals within Category D include those subjected to potentially painful or stressful procedures. In consequence, in this category, it is imperative the utilization of proper anesthetics and/or analgesics in order to diminish the pain and suffering of these animals at the lower level possible.

Chromosomes contain large molecules known as
a DNA
b Lacunae
C Mitochondria
d Viron

Answers

Answer:

a DNA

Explanation:

prove me wrong

|•-•|

Science 6
ME KEMAINING
55:35
Study the image.
Based on the arrOWS, in which direction are air masses
moving?
O from west to east
O from north to south
O toward the equator
O toward the middle latitude

Answers

Answer:

my answer is from west to east

answer ; is A like she said :).

Explanation:

What is the best explanation for the difference in shape between the two drops shown below

Answers

Answer:

A

Explanation:

I think the answer is A because Hexane is a non-polar solvent and A is the only answer choice that says its non polar. Im sorry if it is incorrect

The best explanation for the difference in shape between the two drops given in image is - Option D. glycerin is polar and has greater cohesion than hexane.

Polarity is the physical characteristics of liquid that allows them to stick to other substances which is called adhesion. Polar molecules also attracted to itself, and this physical trait called cohesion. Water's most common form in the air, a droplet is formed due to this cohesion.

Hexane is a nonpolar solvent that has less electro negativity charge therefore, they do not have hydrogen bonding and there is less cohesion in the molecules.Glycerin is a polar solvent that allows its molecules to attract itself that is cohesion present and lead to more of droplet shape.

Thus, the correct answer is - option D.

Learn more about cohesion:

https://brainly.com/question/1724340

How can the arrangement of atoms help explain how the white phosphorus and red phosphorus can both be pure phosphorus substances?

Answers

Answer:Phosphorus is a chemical element with symbol P and atomic number 15. A multivalent nonmetal of the nitrogen group, phosphorus as a mineral is almost always present in its maximally oxidized state, as inorganic phosphate.

Explanation:

Chemical element phosphorus has the atomic number 15 and the letter P in its symbol. Phosphorus, a multivalent nonmetal belonging to the nitrogen group, is generally always found in the form of inorganic phosphate, which is phosphorus in its maximally oxidized state.

What is phosphorus?

The mineral phosphorus, which is also available as a supplement, is naturally present in many foods. It serves the body in a multitude of capacities. It is a crucial component of cell membranes, bone, and teeth. It maintains a healthy range of blood pH and aids in the activation of enzymes.

All tissues and cells must have phosphorus for growth, maintenance, and repair as well as for the creation of DNA and RNA, the genetic building blocks. The balance and usage of other vitamins and minerals, including vitamin D, iodine, magnesium, and zinc, depend on phosphorus as well.

Thus, Chemical element phosphorus has the atomic number 15.

For more information about phosphorus, click here:

https://brainly.com/question/4622631

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Questlon 2 of 10


Which option best describes electromagnetic waves that have enough energy

to change atoms or molecules into ions?


A. Waves with low frequency

B. Non-ionizing radiation

C. Ionizing radiation

D. Waves with long wavelength

Answers

Answer:

I beleive that it is ioniziing radiation

Explanation: ionizing radiation sounds like it turns things into ions hence the word ionizing

The diagram below shows the water cycle

What process is shown at point A
What process is shown at point B
What process is shown at point C

Answers

A: Precipitation
B: Condensation
C: Evaporation

What process is shown at point A  - precipitation

What process is shown at point B  - condensation

What process is shown at point C - evaporation

what is the range of the pH scale

Answers

Answer:

pH is a measure of how acidic/basic water is. The range goes from 0 - 14, with 7 being neutral. pHs of less than 7 indicate acidity, whereas a pH of greater than 7 indicates a base.

Explanation:

The range is from 0-14 until


Which type of energy causes the biggest concerns about its impact on the landscape?

Answers

Answer:

wind energy

Explanation:

The use of wind energy, like any other human action, inevitably affects the environment, and its negative effects are felt in the soil, flora and fauna of the place where the wind farms are installed.

Which individual's reasoning do you agree with more and why?

Answers

Answer:

Your question doesn't make sense. Who is the individual in question?

Explanation:

Adaptive cellular mechanisms are responses to changes in what?

Answers

Answer:

Unsourced material may be challenged and removed. In cell biology and pathophysiology, cellular adaptation refers to changes made by a cell in response to adverse environmental changes. The adaptation may be physiologic(al) (normal) or pathologic(al) (abnormal).

Explanation:

Brainliest plss :)))

*anatomy & physiology question*

if you are at 120X and the field diameter is 8.0 mm what is the field diameter if you go to 30X magnification?

Answers

Answer:

32 mm

Explanation:

The field of view is the total area visible through the microscope . The diameter of the field of view can be measured.

There is an inverse relationship between the magnification and the field diameter. As magnifications decreases, the field diameter increases by the same proportion, and as magnifications increases, the field diameter decreases by the same proportion.

The relationship between field diameter and magnification is:

magnification of A * field diameter of A = magnification of B * field diameter of B

120X * 8 mm = 30X * B

B = 120X / 30X * 8 mm

B = 32 mm = 32000 μm

The field diameter of 30X magnification is 32 mm (32000 μm)

I really need help on this cause i read the assignment and they didn't explain it well. :(

Answers

Explanation:

Sir kindly take a clearer shot it the questions for assistance

Your class is using engineering principles to improve the design of football helmets to prevent brain injury. Your teacher divides you into groups and gives you various supplies (such as tape, bubble wrap, and foam) to create, design, and build a new helmet. Which of these is a benefit of this type of project in STEM education?


Students learn to follow steps provided by their teacher.

Students use household items to create new products.

Students participate and apply engineering principles.

Students become confident in working independently.

Answers

Answer:

B

Explanation:

Answer:

#2

Explanation:

Students use household items to create new products.

plz help me i beg of you!?

Answers

Answer:

abiotic factors

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